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For one thing, she says, the way a peptide is synthesized for research purposes (with a so-called TFA salt) is different and arguably makes it more toxic than an FDA-approved peptide formulated for human use

In the context of Alzheimer's disease, the excessive and uncontrolled generation of superoxide by microglial NADPH oxidase contributes to significant oxidative damage, directly contributing to neurodegeneration and cognitive impairment ( 6.4 Inflammatory cytokines and mitochondrial damage Dysregulated microglial function plays a key role in various neurodegenerative, autoimmune, and viral diseases, such as Alzheimer's and Parkinson's disease

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European Journal of Internal Medicine 2005;16:218