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Commonly reported adverse effects include: Injection site reactions (redness, pain, swelling) Fluid retention (peripheral oedema, joint pain, or carpal tunnel syndrome) related to GH-mediated effects Glucose metabolism changes : tesamorelin can raise blood glucose levels and may worsen insulin resistance

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One of the most studied combinations pairs Cagrilintide with Semaglutide together referred to as CagriSema to investigate complementary appetite and metabolic pathways