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The temperature difference between refrigerated solution and body tissue creates a localized reaction that manifests as stinging or burning

Their use in clinical practice is considered off-label, based on emerging research, clinical experience, and patient-specific therapeutic goals

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During PINK1-PARKIN-induced mitophagy, the selective autophagy receptors OPTN and NDP52 redundantly activate TBK1, which in turn phosphorylates the mitophagy receptors OPTN, NDP52 and p62 to ensure their retention at damaged mitochondria and to facilitate the recruitment of ATG8 family proteins (180, 181)