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By contrast, SGLT2i-relevant processes encompassed increased glycolysis, impaired glucose oxidation, reduction of cellular stress, attenuation of pro-inflammatory signaling, decreased apoptosis, limitation of cytosolic accumulation of deleterious glucose intermediates, modulation of mTOR signaling, suppression of nutrient-deprivation pathways, restoration of mitochondrial health and renewal, enhanced nutrient oxidation and oxidative phosphorylation, reduced accumulation of toxic glucose and lipid by-products, stimulation of ketonaemia, induction of ketone-driven autophagic flux, and regulation of iron handling through increases in cytosolic Fe accompanied by reductions in ferritin and hepcidin levels

collagen synthesis occurs over weeks

Curr Alzheimer Res 13:185197

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Best Pract Res Clin Endocrinol Metab (2008) 22(4):63957.10.1016/j.beem.2008.08.011 288 DagdelenSCinarNErbasT