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Both semaglutide and tirzepatide are currently recommended by the ADA guidelines as treatments with the highest efficacy in glucose lowering and weight reduction, being classified as having very high efficacy for both purposes [6]
Future trials are needed to confirm whether GLP-1 drugs might be effective in preventing Alzheimers disease. Declared interests: Prof Sir John Hardy: I have consulted for Eisai and Eli Lilly Prof Paresh Malhotra: I receive research funding from NIHR, MRC, Dementia Platforms UK, Alzheimers Research UK, the Football Association, British Heart Foundation and Alzheimers Society
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PMID: 42198918 Cell Prolif Development of NAFLD-Specific Human Liver Organoid Models on a Microengineered Array Chip for Semaglutide Efficacy Evaluation
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