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Studies of endotoxin-induced decrease in lipoprotein lipase activity

Using the Broad Institutes Connectivity Map dataset, Pickart and colleagues reported that GHK significantly changed the expression of a very large number of human genes (on the order of thousands when a modest expression-change threshold is applied), up-regulating many and down-regulating others in a pattern the authors interpret as a shift toward a healthier, more repair-competent state

It is important to be precise about what Category 1 reclassification meansand what it does not