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It functions as a critical component of the cellular antioxidant defense system, participating in detoxification reactions, protein folding, and redox homeostasis

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(4) For all experiments, body weights and monitoring were recorded on a weekly basis and are summarised in Appendix Fig

Conclusion GLP-1 has direct chronotropic effects on the heart mediated by GLP-1 receptors in pacemaker cells of the sinus node, inducing changes in action potential morphology and the leading pacemaker site through a calcium signalling response characterized by PKA-dependent phosphorylation of Ca 2+ cycling proteins involved in pacemaking

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