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In vitro, the viral nucleocapsid (N) protein activates interleukin-6 (IL-6) expression through NF-kB binding at the promoter region of the gene [35]

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Interestingly, BSO treatment did not affect SLC25A39 mRNA levels (Extended Data Fig 1c), but could induce SLC25A39 protein accumulation when an SLC25A39 cDNA lacking UTR elements was expressed ectopically under a viral promoter (Extended Data Fig 1d), thereby suggesting regulation at the post-translational level

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