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Emerging tools, such as pharmacogenetic (110) and nutrigenomic (111) tests now facilitate large-scale pharmacogenomic and nutrigenomic analyses, enabling the early identification of genetic variants that affect nutraceutical-drug interactions

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ROS and oxidatively modified macromolecules function as damage-associated molecular patterns (DAMPs), engaging pattern recognition receptors (PRRs) on microglia, including Toll-like receptors (TLRs) and NOD-like receptors (NLRs), to initiate inflammatory cascades (Block et al., 2007)

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