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Depression and suicidal ideation rates similar to general population Examining all four STEP trials, researchers found that 1 percent or fewer of participants reported suicidal ideation or behavior during treatment, with no differences between semaglutide 2.4 mg and placebo

In addition, since the major pathogenesis of T2D in Asians is beta cell dysfunction, incretin-based therapeutic agents exert greater pharmacological actions by ameliorating primary beta cell dysfunction (36, 37)

Treatment decisions are based on individual clinical assessment

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