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FIGURE 1 2.4 Epileptic seizures monitoring Behavioral characterization was measured based on the modified Racines scale (Table 1) (Terzic et al., 2021) and PTZ injections were given every other day until the animals experienced two consecutive score 4 and 5 seizures, indicating the creation of a kindled model (Vasilev et al., 2018)

[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Menegatti S., Guillemot V., Latis E., Yahia-Cherbal H., Mittermller D., Rouilly V., Mascia E., Rosine N., Koturan S., Millot G.A., et al

Synovitisthe swelling of the synovial membraneserves as the front line, where fibroblasts and macrophages swell the ranks, releasing a cytokine storm, in RA, TNF-, IL-6, and harvesting oxidative stress characters all work together as partners in crime to compound and aggravate the situation on the cellular level, as well as at the patient level [5]

Among these, histone modifications like ubiquitination and DNA methylation are important mechanisms regulating gene transcriptional status

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