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One explanation for the necessity to use double exponential fits for the second phase could be that a fraction of the roGFP2 WT (SH) 2 -PfGrx(SSG) intermediates glutathionylates the roGFP2 moiety of another molecule in trans

This ability to generate H2O2, which is capable of diffusing across membranes and acting as a signaling molecule, implies a role for NOX4 in cellular signaling and regulation (100)

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