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Inhibition of CTH by siRNA- mediated knockdown of CTH and the pharmacological inhibition using 10 mM PAG strongly depleted cell viability after 3 days in UACC 62 melanoma cells (Figure 6B)

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Ahmed S, Bogiatzi C, Hackam DG, et al

In addition to labelling misfolded, damaged, aggregation-prone and intact but unneeded proteins for proteasomal degradation, ubiquitylation regulates a multitude of cellular processes, such as transcription, translation, endocytosis, and receptor activity and subcellular localization

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