A 2023 review and meta-analysis found just about a one pound difference between adults with overweight and obesity taking capsaicin compared to controls
Together, these two mechanisms explain why low-dose atropine can paradoxically enhance vagal effects and slow sinoatrial node firing before higher doses shift the balance toward the expected anticholinergic tachycardia
Quick answer: Yes, you can gain weight on semaglutide, and regain after stopping is common because the drugs appetite-suppressing effects wear off
The GLP-1R, upon activation, exerts several metabolic effects including the release of insulin and suppression of appetite, and has, accordingly, become an important target for the treatment for type 2 diabetes (T2D)
Widemann & Italiano, 2018)