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There is a C-to-T single-nucleotide polymorphism at the 718 position (rs713041) located in the 3-untranslated region of the GPX4 gene close to the predicted selenocysteine insertion sequence structure (SECIS, a region of the mRNA required for incorporation of the amino acid Sec into GPX4)

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This was predominant in the male Gclc L-KO mice and was not rescued with Nrf2 deletion (Fig

Cardiac-specific elision of Fth1 (encoding ferritin heavy chain) causes iron dysregulation and increased oxidative stress in the heart, leading to increased sensitivity to ferroptosis induced by iron overload [76]

However, that study also employed a small dose of phosphatidic acid, another soy-based phospholipid.105 Saffron Saffron is a popular herb in central Asian cuisine, and its bioactive compounds called safranals have been implicated in various health benefits