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The complete approval process consists of five major stages: preclinical toxicology studies, Phase I human safety and tolerance testing, Phase II efficacy evaluation, Phase III large-scale controlled clinical trials, and GMP manufacturing site audits

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It's about creating the conditions where change is easy

Methods Modeling Approach Short-term cost-effectiveness was assessed in terms of the cost per patient achieving each endpoint (cost of control), using a bespoke model built in Microsoft Excel (Microsoft Corporation, Redmond, WA) [28]