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Like ADC, CAR-T cells therapy needs to be very specific because of the risk of off-target that could lead to strong side effects even though expected results should be potentially higher regarding its long-term efficacy

The specific outcomes evaluated across each of the studies can be grouped into the three major adverse cardiovascular events (MACE): cardiovascular death, nonfatal MI, and nonfatal stroke, progression of kidney disease, and heart failure hospitalizations

No human trial has measured its effects on sleep

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