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Furthermore, measurements have shown that human breast tumors display plastic deformation (i.e., permanent deformation when subjected to external forces) [144], likely due to the increased collagen concentration and crosslinking observed in the breast tumor microenvironment which can enhance plasticity [145]

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Preclinical studies, mostly in animal models, have explored its effects on a sprawling range of tissuestendons, ligaments, muscles, and even the nervous system