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Not everyone who develops a PE has symptoms of DVT

Several examples have also now emerged suggesting the GH/IGF-1 signaling pathway is relevant to human aging 12 , including the discovery of functional mutations in the IGF-1R gene in individuals with exceptional longevity, resulting in relative IGF-1 resistance 13,14 , and in subjects lacking functional GH receptors (Laron dwarfs) 15

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Figure 1 Figure 2 Figure 3 Figure 4 In the multivariable models, C3DC, C4 and C10:1 were positively associated with age among cases (Additional file 3)