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Classical labeling of bacterial pathogens according to their lifestyle in the host: inconsistencies and alternatives

The stabilization and nuclear translocation of Nrf2 result in the transcription of antioxidant response element-regulated genes such as HO-1, NQO1, GCLC, SOD, catalase, and GPx, which together enhance glutathione synthesis, maintain mitochondrial redox balance, suppress lipid peroxidation, and improve cellular resilience to oxidative insults

This severe glutathione deficit was accompanied by elevated ventricular lactate, a clear biomarker indicating that the brains of these patients are relying on highly inefficient, oxygen-deprived anaerobic metabolism due to mitochondrial stress

By restoring glutathione, GlyNAC helps cells defend against oxidative stress and function at their best

Payette, and J