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Conversely, overexpression of Prx1 prevents ferroptosis in a model of oxygen-glucose deprivation/reperfusion-induced neuronal cell death [143]
Adenosylcobalamin is one of two biologically active forms of vitamin B12, the other being methylcobalamin
Preclinical work with GLP-1R/GIPR/GcgR triple agonists showed that a balanced triple agonist produced greater body-weight loss than semaglutide, tirzepatide, and dual co-agonists in diet-induced obese mice, reducing weight to near-lean levels at the highest doses
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These results suggest that the metformin-induced increase in glucose homeostasis was abolished by inhibition of GLUT1 expression, particularly in the distal intestine
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