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Major metabolic disorders in MDD include abnormalities in lipid metabolism characterized by diminished reverse cholesterol transport (RCT) and heightened atherogenicity, disruptions in protein metabolism resulting in reduced total serum protein and decreased plasma tryptophan availability to the brain, and nutritional immunity with immune-linked alterations in trace elements such as iron and zinc [5, 6]
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Such findings suggest that both the initial injury and subsequent secondary injury caused by the activation of cascades which spread the injury away from the trauma site are involved in the above pathological changes