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Q2: How does receptor binding affinity affect therapeutic outcomes

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Notably, CDKN2A underwent an in-frame deletion (COSMIC variant COSM24418) in patient CAS-E and a hotspot P114L substitution (COSMIC variant COSM753743) of reported functional significance 49 in patient CAS-F

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Another approach is to mitigate oxidative stress by administration of antioxidants such as ascorbate and Nacetyl cysteine

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