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This finding brought together the antioxidant property of UA with the consistently topical concept of oxidative stress as a critical factor in the pathogenesis of PD

doi: 10.1056/NEJMoa2028395 194 FangXDuZDuanCZhanSWangTZhuMet al

Long-term Efficacy and Safety While the first results about tesofensine's effectiveness and safety are positive, it's important to remember that we still need further studies and more data for the long term

The metabolic interplay between the vascular and skeletal systems thus emerges as a therapeutic focal point, in which CIT enhances endothelial responsiveness, leucine promotes muscle anabolic processes, and exercise serves to integrate both systems through hemodynamic and molecular stimuli

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