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Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulation

Nat Rev Mol Cell Biol 22:266282 Lv M, Cai Y, Hou W, Peng K, Xu K, Lu C et al (2022) The RNA-binding protein SND1 promotes the degradation of GPX4 by destabilizing the HSPA5 mRNA and suppressing HSPA5 expression, promoting ferroptosis in osteoarthritis chondrocytes

According to time-lapse microscopy, Ir III -03a was photocytotoxic upon irradiation with visible light (2 s, 465495 nm), inducing apoptosis after 2 h