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Prolonged copper supplementation can depress zinc stores through competitive antagonism at the enterocyte level [6]

Thus, the most reactive hydroxyl radical is able to oxidize molecules such as DNA, phospholipids, and proteins, while the superoxide can generate other free radicals, as well as associate with nitric oxide (NO), and form the peroxynitrite radical (ONOO-), a powerful NO depleted oxidant

Doses above 1,200mg offer no additional benefit and increase the (already low) risk of transient hypotension or sulfur-related side effects

Qiu J, Bosch MA, Zhang C, Rnnekleiv OK, Kelly MJ

Gabapentin may help by: Reducing neural amplification of mast cell signaling Dampening mast cellnerve signaling loops Improving visceral pain thresholds Supporting sleep restoration (which can reduce flare frequency) This positions gabapentin as adjunct burden-reduction therapy