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These conditions can be differentiated from labial melanotic macule by a combination of clinical and histological features

In peripheral blood monocuclear cells from patients with SLE [44] and early rheumatoid arthritis [45], vitamin D 3 significantly decreased the proportion of Th17 cells

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This leads to inflammation in the lining of the joints (synovium), causing painful swelling that can eventually result in bone erosion and joint deformity

de Morais MG, da Vaz B et al (2015) Biologically active metabolites synthesized by microalgae