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The resting tension of aortic rings was adjusted to 1.0 g

Saxagliptin has also been evaluated in five additional trials in patients with type 2 diabetes mellitus: an active-controlled trial comparing add-on therapy with saxagliptin to glipizide in 858 patients inadequately controlled on metformin HCl alone, a trial comparing saxagliptin to placebo in 455 patients inadequately controlled on insulin alone or on insulin in combination with metformin HCl, a trial comparing saxagliptin to placebo in 257 patients inadequately controlled on metformin HCl plus a sulfonylurea, a trial comparing saxagliptin to placebo in 315 patients inadequately controlled on dapagliflozin and metformin HCl, and a trial comparing saxagliptin to placebo in 170 patients with type 2 diabetes mellitus and moderate or severe renal impairment or ESRD

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The most relevant and recent data regarding the anticancer activity of sulforaphane were obtained through an online search of the following scientific databasesPubMed/MedLine, Scopus, Web of Science, and Google Scholarusing the next MeSH terms: Brassica/chemistry, Chemoprevention, Isothiocyanates/metabolism, Isothiocyanates/pharmacology, Isothiocyanates/therapeutic use, Neoplasms/drug therapy, Neoplasms/prevention & control, Biological Products/therapeutic use

However, all three ROS scavengers inhibited shCtrl but not shGDH1 cell death (Extended Data Fig