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10.1016/j.femsle.2005.08.049 [DOI] [PubMed] [Google Scholar] Zhao C., Gao L., Wang C., Liu B., Jin Y., Xing Z

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Together these data demonstrate that in DIO mice the GLP-1 peptide component of MEDI4166, despite being 52- and 37-fold less potent than Ab#2.1_EX4 at mouse GLP-1R in CHO transfected cells and MIN6 -cells respectively (Supplementary Table 9), resulted in more durable glucose control than the non-optimised fusion