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Beyond these costs are the hardships and sacrifices suffered by family members and other caregivers, accompanied by the frustration experienced by health care professionals as patient cognitive abilities slowly decline

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We have preliminary observations in support (Tsutsui et al., 2019), and this could be expanded with a more detailed dissection of the precise transmissible species, target elements (for instance, is the myelinating unit most vulnerable?), and mechanisms of transmission and spread