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Endocr Rev (2012) 33(2):187215

It's usually temporary

Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK

This means giant congenital melanocytic nevus is non-hereditary i.e

However, emerging clinical, pathological, and experimental data suggests that PD pathogenesis may begin in peripheral organs, notably the gastrointestinal (GI) tract [14]

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