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Quad-agonists and even more complex multi-receptor compounds are already in preclinical development

Surprisingly, despite increasing Gcg mRNA, chronic IL-6 treatment does not increase plasma GLP-2 levels suggesting a difference in GLP-1 and GLP-2 transcript or protein stability

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To assess whether GLP-1(2836) can exert direct cardiac effects, we used an ex vivo isolated heart global IRI model under constant coronary perfusion pressure (4) (Figure 1D)

doi: 10.1007/s40520-016-0548-z 226 JiaXTYeTYuanLZhangGJLiuZQDiZLet al