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Autophagy deficiency in neurons results in buildup of ubiquitinated proteins, dystrophy of neural terminals, impairments in synaptic transmission, and eventually, neurodegeneration observed in both neurodegenerative and neurodevelopmental disorders [245, 249, 250]
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However, Taub (2008) describes its implication in the regulation of immune factors, by inhibiting inflammatory cytokine production, more specifically in mediating anti-inflammatory effects on IL-1, TNF-, and IL-6 cytokine expression by T-cells and mononuclear cells via GHS-R, and promoting thymic function
Beyond blood sugar control, this medication offers protection against diabetes-related complications and focuses on the importance of a proper diet, regular exercise, and a personalized treatment approach
Semaglutide is available as both an injectable and an oral tablet
