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4.1 Re-evaluating therapeutic approaches in AD For years, the amyloid cascade hypothesis has been the dominant framework guiding AD research

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We stated in the CY 2026 PFS proposed rule (90 FR 32627 that unless otherwise specified, all ASM participants and ASM beneficiaries would be subject to the provisions at 512.100 through 512.190, which address the following areas: Beneficiary Protections Cooperation in Model Evaluation and Monitoring Audits and Record Retention Rights in Data and Intellectual Property Monitoring and Compliance Remedial Action Innovation Center Model Termination by CMS Limitations on Review Miscellaneous Provisions on Bankruptcy and Other Notifications Reconsideration Review Process We recognize the standard provisions were not intended to encompass all the terms and conditions that would apply to each Innovation Center model, because each model embodies unique design features and implementation plans that may require additional, more tailored provisions, including with respect to payment methodology, care delivery and quality measurement, that would continue to be included in each model's governing documentation

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