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If the thought experiment is performed whereby APAP is considered as a recent compound that was being progressed through drug development today, it would be clear that it is reproducibly hepatotoxic at high doses in laboratory species, but that there are marked species differences in sensitivity (mouse rat)

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Blood was collected, from which plasma was isolated after centrifuging the blood in a 4 C centrifuge at 2000 g for 15 min

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