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LDHB silencing alters mitochondrial morphology, causes lipid peroxidation, and reduces cancer cell viability, which is potentiated by the ferroptosis inducer RSL3
Oncogenic PIK3CA increases the dependency of cancer cells on glutamine by upregulating the expression of mitochondrial GPT2, which catalyzes the transamination reaction that converts glutamate and pyruvate into -KG and alanine 175
Gene expression studies show it modulates over 4,000 human genes, with particular effects on tissue repair, antioxidant defense, and inflammatory regulation (Pickart et al., 2018)
Huang et al., 2022e)
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