However, their efficacy has limitations, particularly in patients with morbid obesity, where they may not produce enough weight loss to control or resolve the disease fully
Bailey CJ, Morales Villegas EC, Woo V, Tang W, Ptaszynska A, List JF
If a GLP-1 medication causes significant appetite reduction, a nursing mother may eat far less than her body requires to sustain milk production
Thus, the technical advances in understanding the distribution and functional roles of GLP-1R across peripheral and central systems continue to inform the development of more effective therapies targeting both metabolic and behavioral domains
Chronic high-fat or high-sugar food intake is associated with changes in the mesolimbic reward system and reward behavior (Li et al., 2011