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One of the first approved weight loss drugs since then was Wegovy

Kramer CM, Borlaug BA, Zile MR, et al (2024) Tirzepatide Reduces LV Mass and Paracardiac Adipose Tissue in Obesity-Related Heart Failure

Back Marcus, A (24 Nov 2020) 'Robert H Unger: Obituary', The Lancet , 396, 1555

Moreover, the first global genome-wide epigenetic analysis in VAT 211 from IR and insulin-sensitive (IS) morbidly obese patients identified a novel IR-related gene, the zinc finger protein 714 (ZNF714) exhibited the highest DNA methylation difference, and its methylation levels is lower in IR patient than in IS patient, consistent with increased transcription levels, such studies provide potential epigenetic biomarkers related to IR in addition to novel treatment targets for the prevention and treatment of metabolic disorders