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10.1001/jama.2021.23619 [DOI] [PMC free article] [PubMed] [Google Scholar] 35.Kadowaki T, Isendahl J, Khalid U, Lee SY, Nishida T, Ogawa W, et al

Over the past few years, due to both appropriate and inappropriate use, the demand for and use of GLP-1 and GIP/GLP-1 receptor agonists have increased substantially, leaving drug manufacturers struggling to keep their supply sufficient to meet these increased needs

This reduced peripheral circulation helps explain why extremities, in particular, feel cold, as theyre receiving less warming blood flow, and our body prioritises core organs

Why GLP-1s cause muscle loss along with fat loss

The breakout worsens or persists beyond 6-8 weeks Purging should resolve within a month or two