The most common side effects of both drugs are gastrointestinal (GI) complaints, but dual agonists may lead to more of these side effects compared to single agonists
Moreover, PIP2 is a substrate for phosphoinositide 3-kinase (PI3K), forming phosphatidylinositol (3,4,5)-trisphosphate (PIP3), a critical docking site for proteins in the insulin signaling pathway, including Akt (Protein Kinase B)
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Although the focus of this review is to examine the impact of selenium and myo-inositol in the context of thyroid disease, there is limited evidence to support the use of myo-inositol alone in the treatment of thyroid disease
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