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[80] History [edit] Historical descriptions of possible PMOS symptoms date to ancient Greece, where Hippocrates described women with "thick, oily skin and absence of menstruation." [81] The earliest known description of what is now recognized as PMOS dates from 1721 in Italy, which described "Young married peasant women, moderately obese and infertile, with two larger than normal ovaries, bumpy, shiny and whitish, just like pigeon eggs"

Blood clots and severe allergic reactions have also been reported

10.3390/nu10101398 20 KoethR

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The following formula was used to calculate the effective annualized sample size: The expected annual numbers of events in the intervention and placebo groups were estimated to be 147 and 177, respectively