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Twenty-four hour pattern of the episodic secretion of cortisol in normal subjects

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Research reveals that senescent cells show upregulation of pro-apoptotic initiators PUMA and BIM while anti-apoptotic guardian BCL-2 is reduced, suggesting these cells are ready to undergo apoptosis but the execution is restrained by the FOXO4-p53 interaction

In senescent cells, FOXO4 sequesters p53, blocking this process and allowing zombie cells to survive and secrete harmful inflammatory signals known as the Senescence-Associated Secretory Phenotype (SASP)