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Notably, the secretory phase is subdivided into three transcriptionally defined stages based on clustering analysis of epithelial single-cell transcriptomes, to ensure consistency with the original publicly available scRNA-seq dataset

Youll need a lab test to rule out deficiency

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Acknowledgements This investigation was funded in part by the National Institutes of Health through grants R01 NS055095 (RAG) and in a facility constructed with support from Research Facilities Improvement Program Grant C06 RR15482 from the National Center for Research Resources, NIH

Therefore, the FOXO1-C/EBP-ATF4 axis not only directly drives proteolysis through the ubiquitin-proteasome system but also indirectly supports these processes by elevating stress response genes like ChaC1 (Oyabu et al., 2022