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Consent to Participate A written informed consent was obtained from each participant

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To view a copy of this licence, visit About this article Cite this article Wang, L., Li, W., Wu, X

Some studies suggest some benefit of adding selenium supplementation to conventional therapy in Graves disease (GD) [75, 76] and in Hashimotos thyroiditis (HT) [77, 78]

2 Materials and methods 2.1 Study design This study was a multi-center, prospective, double-blind, randomized clinical trial aimed to assess the absorption rate and hence bioavailibility of an innovative oral Sucrosomial B12 (Sidevit B12 developed by Pharmanutra S.p.A, Pisa, Italy) in enhancing circulatory B12 levels in healthy deficient adults, compared to various conventional oral B12 supplement formulations, selected randomly from local pharmacies at each participating center