Potency decreases over time even under optimal storage
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It's unclear how a hydrophilic peptide would interact with an enzyme that processes steroid hormones
Furthermore, the solubility and permeability as the fundamental properties of oral absorption will be discussed in-line with biopharmaceutics classification system
The Reuters report on a head-to-head trial against tirzepatide (February 2026) noted CagriSema did not meet a non-inferiority threshold against tirzepatide on average weight loss at 84 weeks
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