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Finally, the horizons and challenges in current and future research areas are also speculated upon

In the mitochondrial pathway, H 2 O 2 increases calcium ion concentrations within the mitochondria [77], regulates Bcl-2 family protein expression and activity, leading to decreased mitochondrial membrane potential, cytochrome c release, and ultimately triggering apoptosis [78]

Biochimica et Biophysica Acta (BBA) General Subjects, 1830(5), 3143-3153

Nuclear localization of human SOD1 and mutant SOD1-specific disruption of survival motor neuron protein complex in transgenic amyotrophic lateral sclerosis mice

Shifting production from darker melanin (eumelanin) to lighter melanin (pheomelanin) in some labmodels