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The Journal of Molecular Endocrinology , 56(2), 127135

The alarming worldwide increase in obesity requires the development of new molecules that increase patient compliance by reducing the frequency of administration, facilitating intake, and reducing the adverse effects of treatments

however, genetics, cytokines, growth factors, hormones, such as estrogens and progesterone and/or their respective receptors, environmental and epigenetics, and the excessive synthesis of extracellular matrix (ECM), have been associated with the pathogenesis of UF (Flake et al., 2003