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Whilst in conventional medical practice B12 deficiency is generally treated with intramuscular injections, it is generally accepted that oral (per os) administration at a high dose is as effective at improving B12 status

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Historical Context and Treatment Before effective treatment, PA was often fatalhence pernicious. Breakthroughs (including Nobel Prize-winning work) led to liver therapy in the 1920s and injectable B12 after WWII