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Furthermore, flow conditions that promote invasion of MDA-MB-231 aggregates in collagen gels trigger the upregulation of mesenchymal (Vimentin and Snail1) and epithelial (E-Cadherin and keratin-8) genes [237]

309 Cd II binding to the MBL site facilitates the assembly of His-rich site and the presence of this second site in turn enhances the metal affinity of the MBL site significantly, i.e., the binding of Cd II in CadR is positively cooperative

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