As highlighted in a recent Medscape report, even a registered dietitian on a GLP-1 found herself consuming fewer than 900 calories a day without realizing it
In addition to blunted monoaminergic neurotransmission, it was also shown that deficiency in neurotrophic factor effects, disturbances in neurogenesis and synaptogenesis, chronic neuroinflammatory processes, and dysregulation of the hypothalamicpituitaryadrenal (HPA) axis can largely contribute to the manifestation of depressive symptoms in patients [3,4,5]
While these findings may reassure clinicians about the safety of GLP-1R agonist use in high-risk individuals and cancer patients, broader validation studies are needed to clarify its prevalence and clinical significance
This medications safety profile has not been studied in patients under the age of 18, pregnant and lactating people, or those with normal BMIs. At the time of publishing, the FDA has only approved three GLP-1 agonists for weight loss: Wegovy (semaglutide), Zepbound (tirzepatide), and Saxenda (liraglutide)
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